Sulfonated Schiff base Sn(IV) complexes as potential anticancer agents
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- 作者：Susanta Hazraa ; h.susanta@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Anup Paula ; Gunjan Sharmab ; Biplob Kochb ; kochbiplob@gmail.com" class="auth_mail" title="E-mail the corresponding author ; M. Fá ; tima C. Guedes da Silvaa ; fatima.guedes@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Armando J.L. Pombeiroa
- 关键词：Sulfonated Schiff base ; Diorgano dinuclear Sn(IV) ; DNA binding ; Cytotoxicity in vitro ; Reactive oxygen species
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：83-95
- 全文大小：2502 K
文摘
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Two Sulfonated Schiff base diorganotin(IV) complexes were synthesized and characterized.
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The DNA binding activities were tested by the UV and fluorescence spectroscopies.
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The cytotoxicity was evaluated against the A-549, HeLa and MDA-MB-231 cancer cells.
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Cell morphology, apoptosis and molecular docking were studied.
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The apoptotic mechanism was proved by the reactive oxygen species generation studies.