Conventional and microwave-assisted synthesis, characterization, DFT calculations, in vitro DNA binding and cleavage studies of potential chemotherapeutic diorganotin(IV) mandelates
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- 作者：Mridula ; Mala Nath ; malanfcy@iitr.ernet.in" class="auth_mail" title="E-mail the corresponding author ; malanfcy@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diorganotin(IV) mandelates ; Microwave-assisted synthesis ; DFT ; Thermogravimetric analyses ; In vitro CT-DNA binding studies ; pBR322 plasmid cleavage
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：348-360
- 全文大小：1872 K
文摘
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Microwave assisted green synthesis of diorganotin(IV) mandelates.
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Their geometries have been optimized by DFT calculations.
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UV–Vis and fluorescence titrations suggest an intercalative mode of binding with CT-DNA.
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They exhibited effective cleavage of supercoiled plasmid pBR322 DNA.