Synthesis of novel copolymer: Poly(p-dioxanone-co-l-phenylalanine)

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• 作者：Bing Wangp>ap>p> ; p>p>bp> ; Chi Map>ap>p> ; p>p>bp> ; Zuo-Chun Xiongp>ap> ; Cheng-Dong Xiongp>ap> ; Quan-Hua Zhoup>cp> ; Dong-Liang Chenp>ap>p> ; p>p>cdl921@yahoo.com.cnp>
• 关键词：Copolymer ; p-Dioxanone ; l-Phenylalanine ; Mechanism
• 刊名：Chinese Chemical Letters
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：24
• 期：5
• 页码：392-396
• 全文大小：681 K

文摘

In order to expand the application of poly(p-dioxanone) or PPDO in biomedical area, a series of novel copolymers were synthesized successfully by one-step, melted copolymerization of p-dioxanone (PDO) and l-phenylalanine N-carboxyanhydride (l-Phe-NCA) monomers. With the in-feed molar ratio of l-Phe-NCA/PDO equal to 1/20, the conversions of the two kinds of monomers were calculated from p>1p>H NMR. The average molecular weight and polydispersity of the copolymer increase with the increasing reaction time and catalyst concentration. However, the conversions of the two kinds of monomers did not change with the reaction conditions. A three-step mechanism is presented and proved by high resolution p>1p>H NMR and IR spectrums.