Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
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- 作者：René ; Fuertiga ; Damiano Azzinnarib ; d ; Giorgio Bergaminib ; d ; Flurin Cathomasb ; c ; Hannes Sigristb ; Erich Seifritzc ; d ; Stefano Vavassorie ; Andreas Luippoldf ; Bastian Hengerera ; Angelo Cecia ; Christopher R. Pryceb ; d ; christopher.pryce@bli.uzh.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Psychosocial stress ; Fear conditioning ; Inflammation ; IDO1 ; Kynurenine pathway ; Monoamines ; Depression ; Anxiety
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：59-72
- 全文大小：905 K
文摘
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Chronic social defeat induces excessive fear conditioning in mice.
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CSD increases kynurenine pathway activity in blood and brain.
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IDO1 inhibition reverses CSD-induced kynurenines.
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IDO1 inhibition reverses CSD-induced excessive fear expression.