Quantitative structure activity relationship (QSAR) modeling was applied to peptides.
New dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from bovine milk were found.
LPVPQ and IPM were relatively potent inhibitors of DPP-IV.
QSAR allowed potency ranking of the competitive DPP-IV inhibitors.
Milk peptides released in the human intestinal tract can inhibit DPP-IV