Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice
PAS-CPPs-GLP-2 (i.n.) exerted antidepressant-like effects in naïve mice. PAS-CPPs-GLP-2 (i.n.) also exerted antidepressant-like effects in ACTH-treated mice. PAS-CPPs-GLP-2 (i.v.) and CPPs-GLP-2 (i.n.) did not affect the FST immobility time. FITC-labeled PAS-CPPs-GLP-2 (i.n.) was distributed through the mouse brain. PAS-CPPs may enhance the i.n. delivery to the brain compared with CPPs only.