Ethnobotany, phytochemistry, toxicology and pharmacological properties of Terminalia sericea Burch. ex DC. (Combretaceae) - A review

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• 作者：N.I. Mongalo^a ; ^b ; L.J. McGaw^a ; ^c ; T.V. Segapelo^d ; J.F. Finnie^a ; J. Van Staden^a ; ^{rcpgd@ukzn.ac.za}
• 关键词：ABTS ; 2 ; 2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt ; AChE ; acetylcholinesterase ; DPPH ; 2 ; 2-diphenyl-1-picryl-hydrazyl ; IC50 ; 50% inhibitory concentration ; LD50 ; 50% lethal dose concentration ; MIC ; minimum inhibitory concentration ; MBC ; minimum bactericidal concentration ; MFC ; minimum fungicidal concentration ; NO ; nitric oxide ; XO ; xanthine oxidase ; ZI ; zone of inhibition ; ppm ; parts per million ; GMRSA ; Gentamicin-resistant Staphylococcus aureus ; COX ; Cyclooxygenase ; 4-
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：24 December 2016
• 年：2016
• 卷：194
• 期：Complete
• 页码：789-802
• 全文大小：805 K
• 卷排序：194

文摘

The use of medicinal plants in the treatment of infections is ancient. A wide variety of ethnotherapeutic properties and pharmacological actions has been attributed to Terminalia sericea. Studies by various groups of investigators reveal that it is a multipurpose medicinal plant used mostly in the treatment of diarrhoea, sexually transmitted infections, skin rashes, tuberculosis and other infections. The current paper is aimed at providing an overview of the ethnomedicinal uses, toxicology, pharmacology and the phytochemistry of Terminalia sericea.Materials and methodsInformation was retrieved using various search engines, including Pubmed, Science Direct, Google Scholar, Scielo, SciFinder and Scopus. The key words used included Terminalia sericea, secondary metabolites, phytochemistry, biological activity, pharmacology, ethnobotanical survey, medicinal uses, safety, toxicology and other related words.ResultsTerminalia sericea is an important medicinal plant which possesses anti-HIV, anti-fungal, anti-bacterial, anticancer, lipolytic, wound healing, antiparasitic, anti-inflammatory and anti-oxidant activity, as the most valuable biological activities, thus lending pharmacological support to the plant's folkloric uses in indigenous medicine. Toxicologically, the extracts and isolated compounds from the plant species may have mild toxic effects. Phytochemically, the plant species possesses valuable compounds including triterpenes, alkaloids and flavonoids which may well contribute to its biological activity.ConclusionsTerminalia sericea contains secondary metabolites which are valuable in the treatment of a variety of human infections, including community acquired infections which may be prevalent in developing countries. The degree of toxicity reported in various extracts warrants further exploration of the cytotoxicity of the plant species, both against normal human cell lines and in vivo. Moreover, the acetylcholinesterase inhibitory and anti-inflammatory effects also need to be further investigated as there are only a few reports from the literature on these aspects. There is also a need to further understand the mode of action of the extracts against various enzymes relating to inflammation. Antioxidant activity of the plant extracts against various forms of free radicals needs to be investigated. Although T. sericea is reported to be used for ethnoveterinary infections, there are no scientific reports on the anti-parasitic activity of the plant species against common animal parasites.