c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells
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- 作者：Lucie Pekarčí ; ková ; a ; b ; Lucia Knopfová ; a ; b ; Petr Bene&scaron ; a ; b ; Jan &Scaron ; mardaa ; smarda@sci.muni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRC ; colorectal carcinoma ; ROS ; reactive oxygen species ; NOX ; NADPH oxidase ; MM ; mitochondrial membrane ; PI ; propidium iodide ; DPI ; diphenyleniodonium chloride ; NADPH ; nicotinamide adenine dinucleotide phosphate ; UCP ; uncoupling protein ; MBSs ; Myb-binding sites
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：924-936
- 全文大小：1843 K
文摘
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c-Myb controls survival of colorectal carcinoma cells treated with cytotoxic agents.
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The c-Myb/NOX1/ROS/p38 signaling axis protects cells from chemotherapy.
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NOX1 is the direct target of the c-Myb transcription factor.