Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug delivery combined with photothermal ablation for targeted cancer therapy
刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:3039-3052
全文大小:3763 K
卷排序:1861
文摘
Reduction responsive diblock copolymer PEG-b-PHEA-LA-FA prepared by RAFT process AuNR Embedded Block Copolymer Micelle encapsulated highly hydrophobic GW627368X. AuNR-BCPM achieved targeted drug delivery and photothermal ablation simultaneously. Photothermal therapy induced cell death via necroptosis or programmed necrosis. Simultaneous PTT and GW627368X delivery enhanced therapeutic response.