The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?
详细信息 查看全文
- 作者：Noureddine Hammada ; b ; 1 ; Monica Rosas-Lemusa ; b ; c ; 1 ; Salvador Uribe-Carvajalc ; Michel Rigouleta ; b ; Anne Devina ; b ; anne.devin@ibgc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：2HG ; 2-hydroxyglutarate ; 6PGD ; 6-phosphogluconate dehydrogenase ; ACC ; acetyl-CoA carboxylase ; ANT ; adenine nucleotide translocase ; ADP ; adenosine diphosphate ; AMP ; adenosine monophosphate ; AMPK ; AMPKinase ; ATP ; adenosine triphosphate ; Fru6P ; fructose 6 phosphate ; Fru1 ; 6BP ; fructose 1 ; 6-biphosphate ; FH ; fumarate hydratase ; G6PDH ; glucose 6 phosphate dehydrogenase ; Glc6P ; glucose 6 phosphate ; HIF ; hypoxia inducible factor ; Hxk2 ; type 2 hexokinase ; IDH ; isocitrate dehydrogenase ; LKB1 ; tumor suppres
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1857
- 期：8
- 页码：1139-1146
- 全文大小：714 K
文摘
- •
The Crabtree and Warburg effects are two well-known deviations of cell energy metabolism.
- •
Metabolite-induced regulations participate in the induction of these effects.
- •
Hexose phosphates act as metabolic messengers and are involved in the Crabtree effect.
- •
Onco-metabolites and metabolites participate in the induction of the phenotypic expression of the Warburg effect.