High resistance barrier to tenofovir alafenamide is driven by higher loading of tenofovir diphosphate into target cells compared to tenofovir disoproxil fumarate
详细信息 查看全文
- 作者：Nicolas A. Margot ; nicolas.margot@gilead.com" class="auth_mail" title="E-mail the corresponding author ; Yang Liu ; Michael D. Miller ; Christian Callebaut
- 关键词：Tenofovir alafenamide ; Tenofovir diphosphate ; Resistance ; Tenofovir disoproxil fumarate ; HIV-1
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：50-58
- 全文大小：909 K
文摘
- •
Treatment with TAF leads to increased TFV-DP levels in PBMCs.
- •
TAF inhibits breakthrough of resistant HIV-1 in vitro.
- •
TAF confers a higher inhibitory quotient (IQ) than TDF.