• 作者：Xiaoli Pan^a ; ¹ ; Guoqiang Fei^a ; ¹ ; Jingwen Lu^a ; ¹ ; Lirong Jin^a ; Shumei Pan^a ; Zhichun Chen^a ; Changpeng Wang^a ; Shaoming Sang^a ; Huimin Liu^a ; Weihong Hu^b ; Hua Zhang^b ; Hui Wang^c ; Zhiliang Wang^c ; Qiong Tan^d ; Yan Qin^d ; Qunying Zhang^e ; Xueping Xie^f ; Yong Ji^g ; Donghong Cui^b ; Xiaohua Gu^h ; Jun Xu^h ; Yuguo Yuⁱ ; ^{yuyuguo@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Chunjiu Zhong^a ; ^{zhongcj@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Alzheimer's disease ; Diagnosis ; Biomarker ; Thiamine metabolites ; Blood
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：155-162
• 全文大小：786 K

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The measurement of blood thiamine metabolites by HPLC as a promising biomarker test for Alzheimer’s disease diagnosis.

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This test is inexpensive, easy to perform and noninvasive which meets the criteria of ideal biomarker for Alzheimer’s disease.

The disturbance of brain glucose metabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate, one of thiamine metabolites, is a critical coenzyme for three key enzymes of glucose metabolism and significantly reduced in brain and blood samples of a small number of Alzheimer's disease patients. Our study demonstrates that the measurement of blood thiamine metabolites, manifested as thiamine diphosphate level and the variable γ representing the best combination of thiamine metabolites and age, exhibits excellent value for Alzheimer's disease diagnosis with inexpensive, easy to perform, noninvasive merits.