Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus
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- 作者：Takaomi Kuriokaa ; b ; Min Young Leea ; Amarins N. Heeringaa ; Lisa A. Beyera ; Donald L. Swiderskia ; Ariane C. Kanickia ; Lisa L. Kabaraa ; David F. Dolana ; Susan E. Shorea ; Yehoash Raphaela ; yoash@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABR ; auditory brainstem response ; ANF ; auditory nerve fiber ; AVCN ; anteroventral cochlear nucleus ; CN ; cochlear nucleus ; CtBP2 ; c-terminal-binding protein 2 ; DCN1 ; molecular layer of the dorsal cochlear nucleus ; DCN2 ; fusiform cell layer of the dorsal cochlear nucleus ; DCN3 ; deep layer of the dorsal cochlear nucleus ; DCs ; Deiters&rsquo ; cells ; DT ; diphtheria toxin ; DTA ; diphtheria toxin fragment A ; DTR ; diphtheria toxin receptor ; EDTA ; ethylenediaminetetraacetic acid ; GCL ; granule cell lamina ; G
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 September 2016
- 年：2016
- 卷：332
- 期：Complete
- 页码：242-257
- 全文大小：3954 K
文摘
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Auditory neurons can survive for at least two months after selective HC ablation.
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Axon caliber and SGN soma size are significantly smaller after selective HC loss, but their density is unchanged.
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Myelin surrounding auditory neurons is maintained in the absence of HCs.
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HCs are indispensable for the GluR2 expression in the peripheral synapses.
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The VGLUT-1 expression in the CN is unchanged two months after DT injection despite complete loss of HCs and deafness.