- 作者：Lauren M. Jansson ; Janet DiPietro ; Andrea Elko
- 关键词：Methadone ; Fetal development ; Substance abuse ; Pregnancy ; Fetal heart rate ; Fetal movement
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2005
- 出版时间：September 2005
- 年：2005
- 卷：193
- 期：3
- 页码：611-617
- 全文大小：317 K
Objective
The purpose of this study was to investigate the effect of methadone on fetal neurobehavioral functions and maternal physiologic indicators.Study design
Forty women attending a substance abuse treatment facility with otherwise uncomplicated pregnancies were evaluated at peak and trough methadone levels. Fetal measures included heart rate, variability, periodic accelerations/decelerations, motor activity, and fetal movement-heart rate coupling. Maternal measures included maternal heart period, variability, electrodermal skin conductance, respiration, and respiratory sinus arrhythmia (RSA). Repeated measure analysis of variance was used to evaluate within-subject changes.
Results
At peak methadone, fetal heart rate was slower, less variable, and displayed fewer accelerations. Fetuses displayed less motor activity, and the integration between heart rate and motor activity was attenuated. Maternal heart rate and skin conductance were unchanged, but methadone administration was associated with lower respiratory rate and RSA, an indicator of parasympathetic tone.
Conclusion
Maternal methadone administration has significant effects on fetal behavioral functions that are independent of maternal effects.