Detection of primary CMV infection in Sudanese pregnant women by IgG avidity test

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• 作者：Mohammed Abubaker Altayeb^a ; Shamsaldin Ibrahim Mokhtar^a ; Mona Eltahir Adam^a ; Salahaldeen Isamail Mohammed^b ; Hassan Hussein Musa^a ; ^{hassanhm@uofk.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CMV ; Avidity index ; Pregnant women ; Sudan
• 刊名：Asian Pacific Journal of Tropical Disease
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：6
• 期：10
• 页码：816-818
• 全文大小：495 K

文摘

To diagnose primary cytomegalovirus (CMV) infection in pregnant women by determining CMV immunoglobulin G (IgG) avidity index.

Methods

Ninety pregnant women with an average age of 23 years were studied. Their demographic data were obtained along with blood samples. The anti-CMV immunoglobulin M (IgM) antibodies were determined on fully automated immuoanalyzer, while the CMV IgG avidity testing was carried out using avidity ELISA assay.

Results

Among the pregnant women, 15.6% were in the first trimester, 30.0% in the second, and 54.4% in the third trimesters. Besides, 40.0% had chronic disease, while the other 60.0% did not. Anti-CMV IgM antibodies and CMV IgG avidity test showed that 1.1% of the pregnant women were CMV IgM positive and 98.9% were CMV IgG positive, respectively. The avidity test revealed the presence of low avidity of CMV IgG antibodies in 1.1% cases while 98.9% cases exhibited high avidity of CMV IgG antibodies.

Conclusions

CMV IgG avidity test was important to distinguish between CMV recent and past infection rather than relying on IgG and IgM only, and IgM is not always indicative for recent or primary CMV infection.