FOXOs in the impaired heart: New therapeutic targets for cardiac diseases

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• 作者：Zhenlong Xin^a ; ^b ; ¹ ; Zhiqiang Ma^c ; ¹ ; Shuai Jiang^d ; ¹ ; Dongjin Wang^a ; Chongxi Fan^c ; Shouyin Di^c ; Wei Hu^b ; Tian Li^b ; Junjun She^e ; ^{junjunshejiaotong@163.com} ; Yang Yang^a ; ^b ; ^{yang200214yy@163.com}
• 关键词：Forkhead box O ; Ischemic cardiac diseases ; Diabetic cardiomyopathy ; Myocardial hypertrophy ; Cardiac regeneration
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：486-498
• 全文大小：1226 K
• 卷排序：1863

文摘

FOXOs are key transcription factors involved in multiple aspects of cardiac diseases. In vivo models require good control of gene transcription, posttranslational modifications and post-transcriptional gene silencing. The cardiac regeneration may be promoted by proper control of FOXO1/3 activity. FOXO1 mainly plays a detrimental role in heart while FOXO3’s actions are influenced by cell type.