An end stage kidney disease predictor based on an artificial neural networks ensemble

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• 作者：Tommaso Di Noia^a ; ^{t.dinoia@poliba.it} ; Vito Claudio Ostuni^a ; Francesco Pesce^b ; ^c ; Giulio Binetti^a ; ^d ; David Naso^a ; Francesco Paolo Schena^b ; ^e ; Eugenio Di Sciascio^a
• 关键词：Clinical decision support system (CDSS) ; Neural networks ensemble ; End stage kidney disease ; Machine learning
• 刊名：Expert Systems with Applications
• 出版年：2013
• 出版时间：1 September, 2013
• 年：2013
• 卷：40
• 期：11
• 页码：4438-4445
• 全文大小：725 K

文摘

IgA Nephropathy (IgAN) is a worldwide disease that affects kidneys in human beings and leads to end-stage kidney disease (ESKD) thus requiring renal replacement therapy with dialysis or kidney transplantation. The need for new tools able to help clinicians in predicting ESKD risk for IgAN patients is highly recognized in the medical field. In this paper we present a software tool that exploits the power of artificial neural networks to classify patients¡¯ health status potentially leading to ESKD. The classifier leverages the results returned by an ensemble of 10 networks trained by using data collected in a period of 38 years at University of Bari. The developed tool has been made available both as an online Web application and as an Android mobile app. Noteworthy to its clinical usefulness is that its development is based on the largest available cohort worldwide.