Late acute graft-versus-host disease is a common complication after allogeneic hematopoietic cell transplantation.

Grades III and IV early-onset acute graft-versus-host disease are risk factors for development of late acute graft-versus-host disease.

Recurrent and de novo late acute graft-versus-host disease are more responsive to therapy than persistent subtype.

Persistent late acute graft-versus-host disease is more likely to progress to chronic graft-versus-host disease.

Persistent late acute graft-versus-host disease has a higher nonrelapse mortality and a worse overall survival than the other 2 subtypes.