Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones
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- 作者：Eisuke Murakamia ; b ; Masataka Tsugea ; b ; c ; Nobuhiko Hiragaa ; b ; Hiromi Kana ; b ; Takuro Uchidaa ; b ; Keiichi Masakia ; b ; Takashi Nakaharaa ; b ; Atsushi Onoa ; b ; Daiki Mikia ; b ; d ; Tomokazu Kawaokaa ; b ; Hiromi Abea ; b ; Michio Imamuraa ; b ; Hiroshi Aikataa ; b ; Hidenori Ochia ; b ; d ; C. Nelson Hayesa ; b ; Tomoyuki Akitae ; Junko Tanakab ; e ; Kazuaki Chayamaa ; b ; d ; chayama@hiroshima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis B virus ; Tenofovir disoproxil fumarate ; Susceptibility ; HBV genotype ; Drug resistance
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：72
- 期：1
- 页码：91-102
- 全文大小：1647 K
文摘
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We compared tenofovir disoproxil fumarate (TDF) susceptibilities between HBV genotype A and C.
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N236T substitution in HBV RT region is significantly associated with TDF susceptibility.
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Genotypic differences in TDF susceptibility were observed between genotypes A and C in vitro and in vivo.