Etravirine inhibits ABCG2 drug transporter and affects transplacental passage of tenofovir disoproxil fumarate
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- 作者：Josef Reznicek ; Martina Ceckova ; Lenka Tupova ; Frantisek Staud ; frantisek.staud@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：P-glycoprotein ; Breast cancer resistance protein ; Pregnancy ; Tenofovir disoproxil fumarate ; Abacavir ; Transplacental pharmacokinetics
- 刊名：Placenta
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：47
- 期：Complete
- 页码：124-129
- 全文大小：769 K
文摘
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Etravirine is an inhibitor of ABCG2 but not ABCB1 in vitro able to inhibit ABCG2-mediated efflux of TDF and abacavir.
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Through inhibition of ABCG2, etravirine increases placental passage of tenofovir disoproxil fumarate from mother to fetus.
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ABCG2-mediated pharmacokinetic DDI of etravirine with ABCG2 substrates during pharmacotherapy of HIV infection may occur.