Cognitive ‘Omics’: Pattern-Based Validation of Potential Drug Targets

详细信息    查看全文

• 作者：Istvá ; n Gyertyá ; n¹ ; ² ; ^{gyertyan.istvan@med.semmelweis-univ.hu}
• 关键词：animal models ; cognitive enhancers ; memory and cognitive disorders ; translational validity
• 刊名：Trends in Pharmacological Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：2
• 页码：113-126
• 全文大小：1892 K
• 卷排序：38

文摘

Despite the abundance of cognitive enhancer mechanisms identified in basic research, drugs approved for cognitive disorders are scarce and of limited efficacy. Although the so-called ‘gold-standard’ animal assays are well suited to the study of fundamental learning processes, they fail to predict clinical efficacy against complex and robust cognitive defects. Preclinical validation of potential drug targets requires new approaches with higher translational value. Here I propose a rodent cognitive test system that encompasses several learning paradigms each modeling a certain human cognitive domain. Cognitive deficits are brought about by several impairing methods and a particular mechanism of action is tested on each defective cognitive function. The outcome is a cognitive efficacy pattern that should then be matched to the cognitive deficit patterns of the clinical disorders. The best fit will highlight the clinical indication with the greatest chance for success.