刊名:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
出版年:2017
出版时间:February 2017
年:2017
卷:1865
期:2
页码:208-219
全文大小:2499 K
卷排序:1865
文摘
TgIMP1 localizes to the inner leaflet of plasma membrane (PM) via dual acylation. The first 11 amino acids are sufficient for PM targeting and the presence of lysine (K7) is critical. Disruption of TgIMP1 gene revealed no invasion defect or any measurable alteration in the lytic cycle of tachyzoites. Immunization with TgIMP1 DNA confers no selective protection to mice challenged with either wild type or IMP1-ko parasites. We present the solution structure of this domain determined from NMR data and describe a new protein fold not seen before.