Amphiphiles with polyethyleneoxide-polyethylenecarbonate chains for hydrophilic coating of iron oxide cores, loading by Gd(III) ions and tuning R₂/R₁ ratio

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• 作者：Alexey Stepanov^a ; ^b ; ^{aleksestepanov@yandex.ru" class="auth_mail" title="E-mail the corresponding author} ; Asiya Mustafina^a ; Svetlana Soloveva^a ; Sonia Kleshnina^a ; Igor Antipin^a ; Ildar Rizvanov^a ; Irek Nizameev^a ; ^c ; Rafael G. Mendes^d ; Mark H. Rü ; mmeli^d ; ^e ; ^f ; Lars Giebeler^d ; Rustem Amirov^b ; Alexander Konovalov^a
• 关键词：Gd(III)-loaded amphiphiles ; Polyethylenecarbonate derivatives ; Dual-mode agents ; Iron-oxide nanoparticles ; Recoating
• 刊名：Reactive and Functional Polymers
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：99
• 期：Complete
• 页码：107-113
• 全文大小：1089 K

文摘

The present work is aimed at the synthesis of hydrophilic colloids with convenient transverse and longitudinal NMR-relaxation times. Core-shell morphology with iron oxide cores and hydrophilic shell enriched by Gd(III) ions is the basis for the colloids with dual-mode relaxivities. Polyethyleneoxide–polyethylenecarbonate derivatives of p-tert-butylphenols are introduced as amphiphiles for efficient hydrophilization of oleate-stabilized iron oxide nanoparticles. The obtained results reveal the easy variation of the synthetic conditions as the route to switch from the recoating to the dissolution of the oleate-stabilized iron-oxide nanoparticles. The length of ethylenecarbonate chains is highlighted as the factor affecting the transverse relaxivity (R₂) and the colloid properties of the synthesized colloids, evaluated from DLS data. The complex ability of ethylenecarbonate chains is the reason for loading of the synthesized colloids by Gd(III) ions in aqueous dispersions at specific conditions. These conditions are introduced herein as a route of gaining in longitudinal relaxivity (R₁) and tuning R₂/R₁ ratio.