Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro
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- 作者：Christine N. Galinskia ; Jeffrey I. Zwickerb ; Daniel R. Kennedya ;
- 关键词：Protein disulfide isomerase ; Red wine ; Quercetin ; French Paradox ; Thiol isomerase
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：169-173
- 全文大小：644 K
文摘
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We determine that red wine inhibits the enzymatic activity of protein disulfide isomerase.
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Quercetin levels in the red wines examined are in the low micromolar range.
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Red wine also inhibits protein disulfide related thiol isomerases ERp5 and ERp57.
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Protein disulfide enzymatic activity is not affected by alcohol levels.