Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage
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- 作者：Vivian Padí ; n-Irizarrya ; 1 ; Emilee E. Coló ; n-Lorenzoa ; Joel Vega-Rodrí ; gueza ; 2 ; Marí ; a del R. Castrob ; Ricardo Gonzá ; lez-Mé ; ndezc ; Sylvette Ayala-Peñ ; ab ; 3 ; Adelfa E. Serranoa ; 3 ; adelfa.serrano@upr.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ART ; artemisinin ; DCF ; dichlorofluorescein ; DCFH ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein ; DHOD ; dihydroorotate dehydrogenase ; DNPH ; dinitrophenylhydrazine ; FP IX ; ferritoprotoporphyrin IX ; FTC ; fluorescein 5-thiosemicarbazide ; GR ; glutathione reductase ; Grx ; Glutaredoxin ; GSH ; glutathione ; GSSG ; glutathione disulfide ; H2O2 ; hydrogen peroxide ; Hb ; hemoglobin ; mtDNA ; mitochondrial DNA ; nDNA ; nuclear DNA ; pbggcs-ko ; P. berghei gamma-glutamylcysteine synthetase knockout ; pbgr-ko ; P. berghei gl
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：43-54
- 全文大小：1845 K
文摘
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Decreased GSH levels correlate with a delay of the ring to schizont transition.
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Damage to the nDNA but not the mtDNA is higher in GSH-deficient parasites.
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Optimal GSH levels are required for parasite normal growth and to avoid nDNA damage.