Immunization with Leishmania donovani protein disulfide isomerase DNA construct induces Th1 and Th17 dependent immune response and protection against experimental visceral leishmaniasis in Balb/c mice
Recombinant Leishmania donovani PDI is recognised in sera of VL patient. Immunization of BALB/c mice with LdPDI as DNA construct leads to enhance the T-cell proliferation. LdPDI-construct has the ability to trigger both Th17 and Th1 cells response in immunized mice. LdPDI-construct vaccination may ensure persistent IL-2 production and show high durability till a longer period of time.