Antifungal rosane diterpenes and other constituents of Hugonia castaneifolia

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• 作者：Lilechi D. Baraza ; Cosam C. Joseph ; Joan J.E. Munissi ; Mayunga H.H. Nkunya ; Norbert Arnold ; Andrea Porzel ; Ludger Wessjohann
• 关键词：Hugonia castaneifolia ; Linaceae ; Antifungal ; Larvicidal ; Rosane diterpenoids ; Himachalenoid ; 2-Hydroxyhenpentacont-2-enal
• 刊名：Phytochemistry
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：69
• 期：1
• 页码：200-205
• 全文大小：147 K

文摘

The rosane diterpenoids hugorosenone [3β-hydroxyrosa-1(10),15-dien-2-one], 18-hydroxyhugorosenone and 18-hydroxy-3-deoxyhugorosenone, and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one were isolated as antifungal constituents of H. castaneifolia Engl. root bark, together with the previously reported di-podocarpanoids hugonone A and hugonone B that were weakly active, and 1(10),15-rosadiene-2β,3β-diol (hugorosenol), 4α-methoxyhimachal-10-en-5β-ol (hugonianene B) and 2-hydroxyhenpentacont-2-enal, and the known compounds tetracosyl-(E)-ferrulate and caryophyllene oxide, all of which were inactive. Hugorosenone also exhibited activity against Anopheles gambiae mosquito larvae. Structural determination was achieved based on spectroscopic data.