Circulating HIV-Specific Interleukin-21+CD4+ T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions
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- 作者：Bruce T. Schultz1 ; 2 ; 3 ; 7 ; Jeffrey E. Teigler1 ; 2 ; 7 ; Franco Pissani1 ; 2 ; 8 ; Alexander F. Oster1 ; 2 ; Gregory Kranias1 ; 2 ; Galit Alter4 ; Mary Marovich1 ; 2 ; 9 ; Michael A. Eller1 ; 2 ; Ulf Dittmer5 ; Merlin L. Robb1 ; 2 ; Jerome H. Kim1 ; 6 ; Nelson L. Michael1 ; Diane Bolton1 ; 2 ; Hendrik Streeck1 ; 2 ; 3 ; hendrik.streeck@uk-essen.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 January 2016
- 年：2016
- 卷：44
- 期：1
- 页码：167-178
- 全文大小：1976 K
文摘
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Circulating IL-21+CD4+ T cells are transcriptionally and phenotypically pTfh cells
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pTfh cells maintained phenotype and function in culture
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Env- or Gag-specific pTfh cells elicited differential quality of help to B cells
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Vaccine-induced pTfh cells were highest in the moderately efficacious RV144 trial