Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system

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• 作者：Megan K. Mulligan^a ; ^{mmulliga@uthsc.edu} ; ^{mulliganmk@gmail.com} ; Khyobeni Mozhui^a ; Ashutosh K. Pandey^a ; Maren L. Smith^b ; Suzhen Gong^a ; Jesse Ingels^a ; Michael F. Miles^b ; Marcelo F. Lopez^c ; Lu Lu^a ; Robert W. Williams^a
• 关键词：C57BL/6J ; DBA/2J ; CIE ; Alcohol ; Addiction ; RNA-seq
• 刊名：Alcohol
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：58
• 期：Complete
• 页码：61-72
• 全文大小：2281 K
• 卷排序：58

文摘

This is the first study to compare expression profiles across 11 brain regions and between two inbred strains following CIE. We report long-lived alterations in expression – a putative chronic alcohol engram – 72 h following chronic alcohol exposure. Several brain regions, including the cortex and hippocampus, show long-lasting enhanced sensitivity to CIE treatment. Strikingly divergent transcriptional responses are observed between strains with 3 times more genes altered by CIE in D2.