- 作者：Meng-yi Wang ; Zhe-yu Niu ; Xiang-Gao ; Li Zhou ; Quan Liao ; lqpumc@126.com" class="auth_mail" title="E-mail the corresponding author ; Yu-pei Zhao ; zhao8028@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：cell division cycle associated 2 ; immunohistochemistry ; prognosis ; pancreatic ductal adenocarcinoma
- 刊名：Chinese Medical Sciences Journal
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：31
- 期：3
- 页码：149-154
- 全文大小：709 K
Methods
This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues. Clinicopathological characteristics between high and low CDCA2 expression were compared. Correlation of CDCA2 expressions with patients’ survival was analyzed using Kaplan-Meier method and Cox regression analysis.
Results
Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues (U=4056.5, P<0.001). Univariate analysis showed that CDCA2 expression [hazard ratio (HR) = 1.574, 95% confidence interval (CI)=1.014-2.443, P=0.043] and node metastasis (HR=1.704, 95%CI=1.183-2.454, P=0.004) were significantly associated with prognosis. Cox regression analysis showed CDCA2 expression was not an independent prognostic risk factor (HR=1.418, 95%CI=0.897-2.242, P=0.135) for PDCA patients. Stratification survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients (HR=2.554, 95%CI=1.446-4.511, P=0.003) or in non-perineural invasion patients (HR=2.290, 95%CI=1.146-4.577, P=0.012).
Conclusions
CDCA2 is highly expressed in PDAC tumor tissue. Although CDCA2 is not an independent prognostic risk factor for PDAC patients, it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.