DIXDC1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) via enhancing p-Akt in Non-Hodgkin's lymphomas
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- 作者：Yu Ouyang ; Fei Zhong ; Qiru Wang ; Linlin Ding ; Peipei Zhang ; Lingling Chen ; Yuchan Wang ; wangyuchan@ntu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chun Cheng ; ntchengchun@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Non-Hodgkin&rsquo ; s lymphomas (NHL) ; DIXDC1 ; Proliferation ; Cell adhesion ; Drug resistance
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：104-111
- 全文大小：2450 K
文摘
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Adhesion of NHL cell lines to HS-5 or FN inhibited cytotoxic drug-induced apoptosis.
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DIXDC1 promoted cell adhesion-mediated drug resistance via the AKT pathway.
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DIXDC1 is a potential therapeutic target for overcoming cell adhesion-mediated drug resistance in NHL.