Inhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion
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- 作者：Xue Wen Weia ; b ; 1 ; Ling Yun Haoa ; c ; 1 ; Su Hua Qia ; qisuhua9999@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：eNOS ; endothelial nitric oxide synthase ; GSNO ; S-nitrosoglutathione ; iNOS ; inducible nitric oxide synthase ; I/R ; ischemia/reperfusion ; JNK ; c-Jun NH2-terminal kinase ; MAPK ; mitogen-activated protein kinase ; MKK4 ; mitogen-activated protein kinase kinase 4 ; MLK3 ; mixed-lineage kinase 3 ; MK-801 ; dizocilpine hydrogen maleate ; NMDAR ; N-methyl-d-aspartate receptor ; nNOS ; neuronal nitric oxide synthase ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; PSD-95 ; postsynaptic density protein-95 ; SDS-PAGE ; sod
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：123-128
- 全文大小：1217 K
文摘
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MKK4 could be S-nitrosylated in rats.
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S-nitrosylation and phosphorylation of MKK4 are mediated by nNOS and NMDAR.
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Treatment with drugs that attenuate cerebral I/R-induced MKK4 S-nitrosylation.