Retinoic acid receptor β enhanced the anti-cancer stem cells effect of β-carotene by down-regulating expression of delta-like 1 homologue in human neuroblastoma cells
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- 作者：Yoo-Sun Kim ; Eunju Kim ; Yoon Jung Park ; Yuri Kim ; yuri.kim@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：β-carotene ; Neuroblastoma ; Cancer stem cells ; Retinoic acid β ; DLK1
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：11 November 2016
- 年：2016
- 卷：480
- 期：2
- 页码：254-260
- 全文大小：1147 K
文摘
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β-carotene up-regulates RARβ in human neuroblastoma cells.
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RARβ regulates anti-cancer stem cell effect of β-carotene by down-regulating DLK1 expression in human neuroblastoma cells.
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β-carotene enhances binding of RARβ to the DLK1 promoter.
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The β-carotene-mediated inhibition of self-renewal capacity in human neuroblastoma cells is regulated by RARβ.