Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification
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- 作者：Imtiaz Khana ; ikhanqau@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sumera Zaibb ; c ; Sadaf Batoold ; Naeem Abbasa ; Zaman Ashrafe ; Jamshed Iqbalc ; Aamer Saeeda ; aamersaeed@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPO ; Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate ; BSA ; bovine serum albumin ; BZD ; benzodiazepine ; DBU ; 1 ; 8-diazabicycloundec-7-ene ; DIPEA ; N ; N-Diisopropylethylamine ; DMAD ; dimethyl acetylenedicarboxylate ; DNA ; Deoxyribonucleic acid ; EGFR ; Epidermal growth factor receptor ; GABA ; Gamma-aminobutyric acid ; MAO ; monoamine oxidase ; MES ; maximal electroshock seizure ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium ; MW ; microwave ; NIS ; N-Iodosuccinimide ; PARP
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：24
- 期：11
- 页码：2361-2381
- 全文大小：3854 K
文摘
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Quinazolines and quinazolinones are useful bioactive scaffolds in medicinal chemistry.
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Mild, efficient and environmentally benign synthetic procedures.
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Mechanistic investigations and synthetic applications.
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Pharmaceutical and agrochemical applications.