Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
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- 作者：Bá ; rbara S. Pinheiroa ; 1 ; 2 ; Cristina Lemosa ; 1 ; 2 ; Fernanda Neutzling Kaufmanna ; Joana M. Marquesa ; Carla S. da Silva-Santosa ; Eugé ; nia Carvalhoa ; Ken Mackieb ; Ricardo J. Rodriguesa ; c ; Rodrigo A. Cunhaa ; d ; Attila Kö ; falvia ; c ; akofalvi@uc.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：[3H]DG ; [3H]-2-deoxy-d-glucose ; [18F]FDG-PET ; [18F]-fluorodeoxyglucose-positron emission tomography ; [3H]GABA ; tritiated γ-aminobutyric acid ; 2-AG ; 2-arachidonoyl-glycerol ; 3Rs ; replacement refinement and reduction of animals in research ; α ; βHD6/12 ; α ; β hydrolase domain-containing protein 6/12 ; ARRIVE ; animals in research reporting in vivo experiments ; CB1R(s) ; cannabinoid CB1 receptor(s) ; DAGLα ; sn-1-diacylglycerol lipase α ; dexa ; dexamethasone ; DMAQB1 ; demethylasterriquinone B1 ; DMSO ; dimethyl
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：222-230
- 全文大小：1365 K
文摘
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CB1 and insulin receptors form physical complex in the rat nucleus accumbens.
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Insulin receptor activation stimulates accumbal glucose uptake.
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Accumbal glucocorticoid receptor activation stimulates endocannabinoid 2-AG release.
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2-AG by activating CB1 receptors, prevents insulin from stimulating glucose uptake.
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This model may explain how dexamethasone may cause cerebral insulin resistance.