Stimulator of interferon genes (STING): A “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity
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- 作者：Alexander Poltoraka ; b ; Alexander.Poltorak@tufts.edu" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Olga Kurmyshkinab ; olya.kurmyshkina@yandex.ru" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Tatyana Volkovab ; VolkovaTO@yandex.ru" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Mouse model ; STING ; DMXAA ; Cancer ; Oncovirus
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：83-91
- 全文大小：626 K
文摘
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Wild-derived mouse strains provide unique phenotypes enabling study regulatory mechanisms by which STING exerts its functions.
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Wild-derived mouse model may be helpful in discovering novel, even unexpected, functions of STING.
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Study of the innate immune signaling networks in wild-derived mouse models is highly relevant to human settings.
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STING emerges as a crucial regulator of signaling pathways that drive DNA virus-associated carcinogenesis.