PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells
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- 作者：Partha Pratim Das1 ; 2 ; 11 ; David A. Hendrix3 ; 10 ; 11 ; Effie Apostolou4 ; 5 ; 12 ; Alice H. Buchner1 ; 6 ; Matthew C. Canver1 ; Semir Beyaz1 ; Damir Ljuboja1 ; Rachael Kuintzle10 ; Woojin Kim1 ; Rahul Karnik4 ; 7 ; Zhen Shao1 ; 13 ; Huafeng Xie1 ; Jian Xu1 ; 14 ; Alejandro De Los Angeles1 ; Yingying Zhang4 ; 7 ; Junho Choe8 ; Don Leong Jia Jun1 ; 9 ; Xiaohua Shen1 ; 15 ; Richard I. Gregory8 ; George Q. Daley1 ; 2 ; Alexander Meissner4 ; 7 ; Manolis Kellis3 ; Konrad Hochedlinger2 ; 4 ; 5 ; Jonghwan Kim1 ; 16 ; Stuart H. Orkin1 ; 2 ; stuart_orkin@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：1 September 2015
- 年：2015
- 卷：12
- 期：9
- 页码：1456-1470
- 全文大小：3325 K
文摘
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PRC2 is required to maintain expression of the maternal Gtl2-Rian-Mirg locus
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PRC2 transcriptionally regulates the Gtl2-Rian-Mirg locus through DNAme at IG-DMR
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IG-DMR serves as an enhancer of the maternal Gtl2-Rian-Mirg locus
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PRC2 prevents de novo DNAme at IG-DMR for maternal Gtl2-Rian-Mirg locus expression