The sub-chronic oral toxicity of 1,3,5-trimethylbenzene in Sprague-Dawley rats
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- 作者：David Adenugaa ; moyinoluwa.d.adenuga@exxonmobil.com" class="auth_mail ; Juan-Carlos Carrillob ; Richard H. Mckeea
- 关键词：123-TMB ; 1 ; 2 ; 3-trimethylbenzene ; 124-TMB ; 1 ; 2 ; 4-trimethylbenzene ; 135-TMB ; 1 ; 3 ; 5-trimethylbenzene ; 5&prime ; -NT ; 5&prime ; -nucleotidase ; ACGIH ; American Conference of Governmental Industrial Hygienists ; ALT ; alanine aminotransferase ; AP ; alkaline phosphatase ; ASVCP ; American Society for Veterinary Clinical Pathology ; BWA ; animal body weight ; BWH ; human body weight ; DMBA ; dimethyl benzoic acid ; DMHA ; dimethyl hippuric acid ; DNEL ; derived no effect level ; ECETOC ; European Center for Ecotoxicology an
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：July 2014
- 年：2014
- 卷：69
- 期：2
- 页码：143-153
- 全文大小：528 K
文摘
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Oral exposure to 1,3,5-trimethylbenzene induced increased liver and kidney weights.
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Liver weight effects were a normal adaptive response to higher metabolic load.
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Kidney weight effects were male rat-specific with no associated histopathology.
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A provisional RfD of 1.2 mg/kg/day, based on a NOAEL/LOAEL approach, is proposed.
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An oral population DNEL, analogous to an oral RfD, is proposed.