DNMT1, DNMT3A and DNMT3B Polymorphisms Associated With Gastric Cancer Risk: A Systematic Review and Meta-analysis

详细信息    查看全文

• 作者：Hongjia Li^a ; ¹ ; Wen Li^a ; ¹ ; Shanshan Liu^a ; Shaoqi Zong^a ; Weibing Wang^b ; Jianlin Ren^a ; Qi Li^c ; Fenggang Hou^a ; ^{fghou555@126.com} ; Qi Shi^a ; ^{stevenshi_qi@hotmail.com}
• 关键词：DNA methyltransferase ; Single nucleotide polymorphism ; Gastric cancer ; Meta-analysis ; Systematic review
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：125-131
• 全文大小：802 K
• 卷排序：13

文摘

DNMT1, DNMT3A and DNMT3B polymorphisms are associated with gastric cancer (GC) risk, in which rs16999593 and rs1550117 might contribute to GC and rs1569686 could be a protective factor against carcinogenesis. Significant DNMTs polymorphisms were particularly found in people from Chinese Jiangsu province. PCR-RFLP was a sensitive method to discover significant DNMTs polymorphisms.Research in context Genetic factors play a crucial role in GC risk. DNMTs genes were associated with occurrence or decrease of various tumors. But the effects of DNMTs on gastric cancer (GC) were not clear. Now our results proved that two and one variations in DNMTs were associated with GC, indicating a range of effects from the increased to the reduced. By using these variations as biomarkers, it is feasible to estimate the risk of acquiring GC and thus formulate timely preventive strategy.