文摘
DNMT1, DNMT3A and DNMT3B polymorphisms are associated with gastric cancer (GC) risk, in which rs16999593 and rs1550117 might contribute to GC and rs1569686 could be a protective factor against carcinogenesis. Significant DNMTs polymorphisms were particularly found in people from Chinese Jiangsu province. PCR-RFLP was a sensitive method to discover significant DNMTs polymorphisms.Research in context Genetic factors play a crucial role in GC risk. DNMTs genes were associated with occurrence or decrease of various tumors. But the effects of DNMTs on gastric cancer (GC) were not clear. Now our results proved that two and one variations in DNMTs were associated with GC, indicating a range of effects from the increased to the reduced. By using these variations as biomarkers, it is feasible to estimate the risk of acquiring GC and thus formulate timely preventive strategy.