- 作者：Hadassa A. Hofman ; Paul Knaapen ; Ronald Boellaard ; Olga Bondarenko ; Marco J.W. Gö ; tte ; Willem G. van Dockum ; Cees A. Visser ; Albert C. van Rossum ; Adriaan A. Lammertsma ; Frans C. Visser
- 关键词：Gated oxygen 15– ; labeled carbon monoxide positron emission tomography ; magnetic resonance imaging ; left ventricular volumes ; left ventricular ejection fraction
- 刊名：Journal of Nuclear Cardiology
- 出版年：2005
- 出版时间：November-December 2005
- 年：2005
- 卷：12
- 期：6
- 页码：639-644
- 全文大小：269 K
Background
Positron emission tomography (PET) with inhaled oxygen 15–labeled carbon monoxide (CO) is used as a marker of myocardial blood pool. Only a limited number of studies with small numbers of patients have reported on the assessment of left ventricular (LV) volumes by use of O-15–labeled CO. The aim of this study was to compare LV volumes and function as measured by routinely acquired blood pool images by use of gated O-15–labeled CO PET with the reference technique, cardiovascular magnetic resonance imaging (MRI).Methods and Results
Thirty-four subjects with a varying degree of LV function were studied. LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were determined by both MRI and gated PET by use of O-15–labeled CO. Volumes were comparable with respect to LVEDV (196 ± 83 and 192 ± 91 mL, respectively; P = not significant). LVESV, however, was slightly overestimated by PET (119 ± 85 and 136 ± 94 mL, respectively; P < .05), resulting in a significant underestimation of LVEF (44 % ± 19 % and 35 % ± 18 % , respectively; P < .05). Observed correlations for LVEDV, LVESV, and LVEF were 0.90, 0.96, and 0.86, respectively (all P < .01).
Conclusions
Gated O-15–labeled CO PET measurements of LVEDV, LVESV, and LVEF show good correlation with MRI over a wide range of LV volumes during routinely acquired blood pool images. LVEF, however, may be underestimated compared with MRI.