Fatty acids as modulators of neutrophil recruitment, function and survival

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• 作者：Hosana G. Rodrigues^a ; ^{hosana.rodrigues@fca.unicamp.br" class="auth_mail" title="E-mail the corresponding author} ; Fabio Takeo Sato^b ; Rui Curi^c ; ¹ ; ^{ruicuri@icb.usp.br" class="auth_mail" title="E-mail the corresponding author} ; Marco A.R. Vinolo^b ; ¹ ; ^{mvinolo@unicamp.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Butyric acid (PubChem CID 264) ; Acetic acid (PubChem CID 176) ; Propionic acid (PubChem CID 1032) ; Palmitic acid (PubChem CID 985) ; Stearic acid (PubChem CID 5281) ; Eicosapentaenoic acid (PubChem CID 446284) ; Docosahexaenoic acid (PubChem CID 445580) ; Linoleic acid (PubChem CID 864) ; Oleic acid (PubChem CID 445639)
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 August 2016
• 年：2016
• 卷：785
• 期：Complete
• 页码：50-58
• 全文大小：1455 K

文摘

Neutrophils are well-known to act in the destruction of invading microorganisms. They have also been implicated in the activation of other immune cells including B- and T-lymphocytes and in the resolution of inflammation and tissue regeneration. Neutrophils are produced in the bone marrow and released into the circulation from where they migrate to tissues to perform their effector functions. Neutrophils are in constant contact with fatty acids that can modulate their function, activation and fate (survival or cell death) through different mechanisms. In this review, the effects of fatty acids pertaining to five classes, namely, long-chain saturated fatty acids (LCSFAs), short-chain fatty acids (SCFAs), and omega-3 (n-3), omega-6 (n-6) and omega-9 (n-9) unsaturated fatty acids, on neutrophils and the relevance of these effects for disease development are discussed.