Environmental ozone exposure and oxidative DNA damage in adult residents of Florence, Italy
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- 作者：Domenico Palli ; Francesco Sera ; Lisa Giovannelli ; Giovanna Masala ; Daniele Grechi ; Benedetta Bendinelli ; Saverio Caini ; Piero Dolara ; Calogero Saieva
- 关键词：Environmental pollution ; Ozone ; DNA oxidative damage ; Smoking ; Occupational exposure
- 刊名：Environmental Pollution
- 出版年：2009
- 出版时间：May 2009
- 年：2009
- 卷：157
- 期：5
- 页码：1521-1525
- 全文大小：167 K
文摘
In 71 adults residing in Florence, Italy, enrolled in a prospective study, we investigated the correlation between individual levels of oxidative DNA damage detected by the Comet assay in circulating lymphocytes, and a specific ozone exposure score calculated in 10 different time-windows (0–5 to 0–90 days) before blood drawing, based on daily measurements provided by the local environmental monitoring system.
Overall, statistically significant positive correlations between average ozone concentrations and DNA damage emerged in almost all time-windows considered; correlations were more evident among males, non-smokers, and traffic-exposed workers. Multivariate regression analyses taking into account selected individual characteristics, showed an independent effect on DNA damage of average ozone concentrations in the last 60–90 days before blood drawing. Local residents showed a divergent pattern with correlations restricted to shorter time-windows.
Our results suggest that ozone concentrations at ground levels modulate oxidative DNA damage in circulating lymphocytes of residents of polluted areas.