- 作者：Alberto Cordero ; acorderofort@gmail.com ; José ; Moreno-Arribas ; Vicente Bertomeu-Gonzá ; lez ; Pilar Agudo ; Beatriz Miralles ; M. Dolores Masiá ; Ramó ; n Ló ; pez-Palop ; Vicente Bertomeu-Martí ; nez
- 关键词：Lipoproteí ; nas de alta densidad ; Dolor torá ; cico ; Sí ; ndrome coronario agudo ; Cardiopatí ; a isqué ; mica
- 刊名：Revista Espa?ola de Cardiolog¡§aa
- 出版年：2012
- 出版时间：April, 2012
- 年：2012
- 卷：65
- 期：4
- 页码：319-325
- 全文大小：309 K
Introduction and objectives
The role of high-density lipoproteins in the context of acute chest pain has not been well characterized. The objective of this study was to determine the relative contribution of lipid profile to the risk of acute coronary syndrome in patients admitted to a cardiology ward for chest pain.
Methods
We included all consecutive admissions in a single cardiology department over a period of 10 months and 1-year follow-up was performed.
Results
In total, 959 patients were included: 457 (47.7 % ) were diagnosed with non-ischemic chest pain, 355 (37 % ) with non-ST-elevation acute coronary syndrome, and 147 (15.3 % ) with ST-elevation acute coronary syndrome. Prevalence of high-density lipoproteins <40 mg/dL was 54.6 % , and was higher in patients with acute coronary syndrome (69.4 % vs 30.6 % ; P<.01). The prevalence of acute coronary syndrome increased with reductions in mean high-density lipoproteins. Age, active smoking, diabetes, fasting glucose >100 mg/dL, and high-density lipoproteins <40 mg/dL were independently associated with acute coronary syndrome, and low high-density lipoproteins was the main associated factor (odds ratio, 4.11; 95 % confidence interval, 2.87-5.96). Survival analysis determined that, compared with non-ischemic chest pain, the presence of acute coronary syndrome was associated with significantly greater risk of all-cause and cardiovascular mortality.
Conclusions
Low levels of high-density lipoproteins cholesterol (?0 mg/dL) were independently associated with a diagnosis of acute coronary syndrome in patients hospitalized for chest pain, with an inverse relationship between lower levels of high-density lipoproteins and prevalence of acute coronary syndrome.
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