Notch and T cell malignancy
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- 作者：Zweidler-McKay ; Patrick A. ; Pear ; Warren S.
- 关键词：CSL ; Leukemia ; Oncogene ; Hematopoiesis ; Development
- 刊名：Seminars in Cancer Biology
- 出版年：2004
- 出版时间：October, 2004
- 年：2004
- 卷：14
- 期：5
- 页码：329-340
- 全文大小：239 K
文摘
Notch signaling is required for normal T cell development. However, Notch expression must be precisely regulated as constitutive Notch signaling leads to T cell lymphomas. Recent evidence has provided insights into potential mechanisms of Notch-mediated lymphomagenesis and its relationship to T cell development. The evidence suggests that Notch likely interacts with several important cellular pathways and can cooperate with other oncogenes during lymphomagenesis. In particular, Notch appears to modulate pre-TCR signaling, inhibit the E2A pathway, and in murine leukemia models, frequently cooperates with Myc, E2A-PBX and dominant negative Ikaros dysregulation. This review will present current knowledge in these areas and explore theories on Notch-mediated T cell lymphomagenesis.