Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study

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• 作者：Stephany Vasco Ferreira^a ; ^{stephanyferreira3@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Flá ; via Caló ; Aquino Xavier^a ; ^{f.calo@uol.com.br" class="auth_mail" title="E-mail the corresponding author} ; Maria da Conceiç ; ã ; o Andrade de Freitas^b ; Fá ; bio Daumas Nunes^c ; ^{fadnunes@usp.br" class="auth_mail" title="E-mail the corresponding author} ; Clarissa Araú ; jo Gurgel^a ; ^{gurgel.clarissa@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Maria Cristina Teixeira Cangussu^d ; ^{cangussu@ufba.br" class="auth_mail" title="E-mail the corresponding author} ; Manoela Domingues Martins^e ; ^{manomartins@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Valé ; ria Souza Freitas^f ; ^{valeria.souza.freitas@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jean Nunes dos Santos^a ; ^{jeanunes@ufba.br" class="auth_mail" title="E-mail the corresponding author} ; ^{jeanpatol@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mast cells ; Angiogenesis ; Oral reactive lesions
• 刊名：Pathology - Research and Practice
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：212
• 期：9
• 页码：761-766
• 全文大小：4604 K

文摘

In view of the similarity of clinicopathological features between reactive lesions of the oral cavity, the objective of the present study was to investigate the density of MCs (mast cells) and microvessels in a series of these lesions. Thirty-seven cases of reactive lesions including fibrous hyperplasia (FH, n = 10), inflammatory fibrous hyperplasia (IFH, n = 10), peripheral giant cell lesion (PGCL, n = 10) and lobular capillary hemangioma (LCH, n = 7) were investigated using immunohistochemistry for mast cell tryptase and CD34. For comparative purposes, central giant cell lesions (CGCL, n = 5) were included. A higher MC density was observed in LCH (37.01), while CGCL exhibited the lowest density (n = 8.14). There was a significant difference in MC density when all reactive lesions were compared to CGCL (p = 0.001). The largest mean density of microvessels was observed in LCH (n = 21.69). The smallest number was observed in CGCL (n = 6.24). There was a significant difference in microvessel density when the reactive lesions were compared to CGCL (p = 0.003). There was a significant and direct correlation between the density of MCs and microvessels only for IFH (p = 0.048) and CGCL (p = 0.005). A significant and direct correlation between the mean density of MCs and microvessels was observed when the reactive lesions were analyzed as a whole (p = 0.005). Our results suggest that mast cells contribute to the connective tissue framework and angiogenic function, as well as the development, of reactive lesions of the oral cavity, including FH, IFH, LCH and PGCL.