Critical ages in the life course of the adult brain: nonlinear subcortical aging

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• 作者：Anders M. Fjell ; Lars T. Westlye ; H?kon Grydel ; Inge Amlien ; Thomas Espeseth ; Ivar Reinvang ; Naftali Raz ; Dominic Holl ; Anders M. Dale ; Kristine B. Walhovd ; Alzheimer Disease Neuroimaging Initiative
• 关键词：Aging ; Magnetic resonance imaging ; Longitudinal ; Trajectory ; Atrophy ; Amygdala ; Cerebral cortex ; Hippocampus ; Thalamus ; White matter
• 刊名：Neurobiology of Aging
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：34
• 期：10
• 页码：2239-2247
• 全文大小：1904 K

文摘

Age-related changes in brain structure result from a complex interplay among various neurobiological processes, which may contribute to more complex trajectories than what can be described by simple linear or quadratic models. We used a nonparametric smoothing spline approach to delineate cross-sectionally estimated age trajectories of the volume of 17 neuroanatomic structures in 1100 healthy adults (18-94 years). Accelerated estimated decline in advanced age characterized some structures, for example hippocampus, but was not the norm. For most areas, 1 or 2 critical ages were identified, characterized by changes in the estimated rate of change. One-year follow-up data from 142 healthy older adults (60-91 years) confirmed the existence of estimated change from the cross-sectional analyses for all areas except 1 (caudate). The cross-sectional and the longitudinal analyses agreed well on the rank order of age effects on specific brain structures (Spearman ¦Ñ?= 0.91). The main conclusions are that most brain structures do not follow a simple path throughout adult life and that accelerated decline in high age is not the norm of healthy brain aging.