A Comparison of the Quality of Life of Patients With an Entirely Subcutaneous Implantable Defibrillator System Versus a Transvenous System (from the EFFORTLESS S-ICD Quality of Life Substudy)

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• 作者：Susanne S. Pedersen ; PhD^a ; ^b ; ^c ; ^{sspedersen@health.sdu.dk" class="auth_mail" title="E-mail the corresponding author} ; Mirjam H. Mastenbroek ; PhD^d ; Nathan Carter ; MSc^e ; Craig Barr ; MD ; PhD^f ; Petr Neuzil ; MD ; PhD^g ; Marcoen Scholten ; MD ; PhD^h ; Pier D. Lambiase ; PhDⁱ ; Lucas Boersma ; MD ; PhD^j ; Jens B. Johansen ; MD ; PhD^b ; Dominic A.M.J. Theuns ; PhD^c
• 刊名：The American Journal of Cardiology
• 出版年：2016
• 出版时间：15 August 2016
• 年：2016
• 卷：118
• 期：4
• 页码：520-526
• 全文大小：701 K

文摘

The first clinical results from the Evaluation of Factors Impacting Clinical Outcome and Cost Effectiveness of the subcutaneous implantable cardioverter defibrillator (EFFORTLESS S-ICD) Registry on the entirely S-ICD system are promising, but the impact of the S-ICD system on patients' quality of life (QoL) is not known. We evaluated the QoL of patients with an S-ICD against an unrelated cohort with a transvenous (TV)-ICD system during 6 months of follow-up. Consecutively implanted patients with an S-ICD system were matched with patients with a TV-ICD system on a priori selected variables including baseline QoL. QoL was measured with the Short-Form Health Survey at baseline, 3, and 6 months after implant and compared using multivariable modeling with repeated measures. Patients with an S-ICD (n = 167) versus a TV-ICD system (n = 167) did not differ significantly on physical (p = 0.8157) and mental QoL scores (p = 0.9080) across baseline, 3, and 6 months after implantation in adjusted analyses. The evolution in physical (p = 0.0503) and mental scores (p = 0.3772) during follow-up was similar for both cohorts, as indicated by the nonsignificant interaction effect for ICD system by time. Both patients with an S-ICD system and a TV-ICD system experienced significant improvements in physical and mental QoL between time of implant and 3 months (both p's <0.0001) and between time of implant and 6 months (both p's <0.0001) but not between 3 and 6 months (both p's >0.05). In conclusion, these first results show that the QoL of patients with an S-ICD versus TV-ICD system is similar and that patients with either system experience improvements in QoL on the short term.