Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue
详细信息 查看全文
- 作者：Delphine Duteil1 ; Milica Tosic1 ; Franziska Lausecker1 ; Hatice Z. Nenseth1 ; Judith M. Mü ; ller1 ; Sylvia Urban1 ; Dominica Willmann1 ; Kerstin Petroll1 ; 2 ; Nadia Messaddeq3 ; Laura Arrigoni4 ; Thomas Manke4 ; Jan-Wilhelm Kornfeld5 ; Jens C. Brü ; ning5 ; Vyacheslav Zagoriy6 ; Michael Meret6 ; Jö ; rn Dengjel7 ; Toufike Kanouni8 ; Roland Schü ; le1 ; 9 ; 10 ; 11 ; roland.schuele@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：lysine-specific demethylase 1 ; brown adipose tissue ; epigenetics ; lipid metabolism ; white adipose tissue ; adipocyte ; CoREST ; thermogenesis ; obesity ; carbohydrate metabolism
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：1008-1021
- 全文大小：3194 K
文摘
- •
Loss of Lsd1 in brown adipocytes induces a brown-to-white fat cell conversion
- •
Lsd1 controls BAT- and WAT-selective genes via a dual mechanism
- •
Lsd1 deletion in brown adipocytes shifts oxidative to glycolytic metabolism
- •
Lsd1 controls thermogenesis in BAT to counteract obesity