Soluble MICA-NKG2D interaction upregulates IFN-纬 production by activated CD3^{鈭?/sup>CD56+ NK cells: Potential impact on chronic graft versus host disease}

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• 作者：Wahid Boukouaci ; Reem Al-Daccak ; Nicolas Dulphy ; Laura Lauden ; Kahina Amokrane ; Catherine Fortier ; Fran莽ois Marzais ; Meriem Bennabi ; Regis Peffault de Latour ; Gerard Socie ; Antoine Toubert ; Dominique Charron ; Rajagopal Krishnamoorthy ; Ryad Tamouza
• 关键词：MICA ; MHC class I chain-related molecule A ; sMICA ; soluble MICA ; mbMICA ; membrane-bound MICA ; IFN-纬 ; interferon gamma ; IL ; interleukin ; NK ; natural killer ; NKG2D ; natural killer group 2-member D ; allo-HSCT ; allogeneic hematopoietic stem cell transplantation ; cGvHD ; chronic graft versus host disease
• 刊名：Human Immunology
• 出版年：December, 2013
• 年：2013
• 卷：74
• 期：12
• 页码：1536-1541
• 全文大小：1123 K

文摘

A soluble isoform of MHC class I chain-related molecule A (soluble MICA), generated by proteolytic shedding from the membrane-bound MICA of various tumor cells, has been shown to downregulate both the expression of natural killer group 2-member D receptor and the cytotoxic function of effectors cells and was postulated as a mechanism for tumor immune evasion. Its effect on the expression of cytokines by the effector cells remained unexplored. Here we demonstrate that the sMICA molecules upregulate interferon gamma expression by interleukin-12/interleukin-18-activated CD3^{鈭?/sup>CD56+ natural killer cells, witnessing the pro-inflammatory effect of soluble MICA. Overall, these data are in line with our previous observations that the raised serum levels of soluble MICA, following allogeneic hematopoietic stem cell transplantation, confer susceptibility to and the presence of pre-transplantation anti-MICA antibodies in the patient鈥檚 serum confer protection against chronic graft versus host disease.}