- 作者：Erik J. Kramer ; Blake M. Bodendorfer ; Dominique Laron ; Jason Wong ; Hubert T. Kim ; Xuhui Liu ; Brian T. Feeley
- 关键词：Basic Science Study ; Animal Model
- 刊名：Journal of Shoulder and Elbow Surgery
- 出版年：December, 2013
- 年：2013
- 卷：22
- 期：12
- 页码：1702-1709
- 全文大小：1782 K
Background and hypothesis
Rotator cuff tears are the most common injury seen by shoulder surgeons. Glenohumeral osteoarthritis develops in many late-stage rotator cuff tear patients as a result of torn cuff tendons, termed 鈥渃uff tear arthropathy.鈥?However, the mechanisms of cuff tear arthropathy have not been fully established. It has been hypothesized that a combination of synovial and mechanical factors contribute equally to the development of cuff tear arthropathy. The goal of this study was to assess the utility of this model in investigating cuff tear arthropathy.Materials and methods
We used a rat model that accurately reflects rotator cuff muscle degradation after massive rotator cuff tears through either infraspinatus and supraspinatus tenotomy or suprascapular nerve transection. Using a modified Mankin scoring system, we found significant glenohumeral cartilage damage after both rotator cuff tenotomy and suprascapular nerve transection after only 12 weeks.
Results
Cartilage degeneration was similar between groups and was present on both the humeral head and the glenoid. Denervation of the supraspinatus and infraspinatus muscles without opening the joint capsule caused cartilage degeneration similar to that found in the tendon transection group.
Conclusions
Our results suggest that altered mechanical loading after rotator cuff tears is the primary factor in cartilage degeneration after rotator cuff tears. Clinically, understanding the process of cartilage degeneration after rotator cuff injury will help guide treatment decisions in the setting of rotator cuff tears.